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Based on systemic steroids use, patients who were using steroids for different indications constituted the study population, and those with no steroids use were clustered as a control group(Fig. 2). Figure 2 View largeDownload slide Kaplan–Meier analysis of adverse events related to chronic use of systemic corticosteroids in patients with advanced prostate cancer. Figure 2 View largeDownload slide Kaplan–Meier analysis of adverse events related to chronic use of systemic corticosteroids in patients with advanced prostate cancer. Hepatic Adverse Events The median number of hepatic events was 1.5 (range, 0.5 to 5). An increased rate of hepatic isthmus occurred (1.8%; range, 0.5 to 4) in patients who used steroids for different indications (Table 2). Table 2. Case/Control Group Mean (SE) Number (percent) Number in Pooled Group (n) Number in Pooled Group (n) No. of Hepatic Events 0–2 4 (2.5) 1.5 (0.4, 9) 0–9 3 (2.0) 1.5 (0.4, 9) 5.0 (3.1) ≥3 9 (2.8) 2.0 (0.6, 11) 1.5 (1.0, 4) 0.5–2 0 3 (1.7) 3.0 (2.0) 0.5–1 0 4 (2.9) 5.0 (5.2) 3.5 (3.6, 4.2) 1.0–2 8 (3.8) 1.5 (1.0, 4.0) 2.0 (1.0, 4.0) 3.0–4 0 8 (4.2) 0.0 (0.0, 0.7) 0.1 (0.0, 0.7) 4.0–5 0 0 0 0.0 (0.0, 9.75) 3.0 (0.5, 3.9) 0.5–2 0 2 (0.3) 0 (0.0, 1.0) 2.0 (0.5, 3.0) Table 2. Case/Control Group Mean (SE) Number (percent) Number in Pooled Group (n) Number in Pooled Group (n) No. of Hepatic Events 0–2 4 (2.5) 1.5 (0.4, 9) 0–9 3 (2.0) 1.5 (0.4, 9) 5 Similar articles: